How do embryologists grade embryos?

The success of ICSI treatment depends on the quality of embryos. In medical procedure, embryo grading is used to evaluate and select the healthy embryos with the best quality before embryo transfer.

 

At Prime Fertility Clinic, our embryologists perform embryo grading. The fertility specialists assess embryos during 2 stages of embryo development which are Cleavage stage and Blastocyst stage as following details:

 

Cleavage stage

The embryo assessment of Prime Fertility Clinic refers to an international criteria of Istanbul Consensus Scoring System. Considering cell morphology and symmetry, embryos are simply divided in 3 groups.

  • Grade 1 (Good quality): The embryos that consist of blastomeres or an increased number of cells from cell division. Each cell has a nice round shape, equal size, no fragmentation (small fragments or broken pieces of abnormal cells of embryo). However, fragmentation less than 10% will be accepted. Embryos in this group are more likely to reach Blastocyst stage.

 

  • Grade 2 (Fair quality): The embryos that consist of a fair quality of blastomeres or slightly different cell sizes from cell division. 10-25% Fragmentation will be found in this group.

 

  • Grade 3 (Poor quality): Blastomeres or cell division appears in various cell sizes. Showing more than 25% fragmentation.

 

Blastocyst stage

The stage that an embryo reaches 5-6 days after fertilization. Embryo grading at Prime Fertility Clinic refers to the international scoring system for evaluating blastocysts proposed by Gardner and Schoolcraft (1999). Blastocyst grading is defined by the appearance of inner cell mass and trophectoderm which are rated either A, B, C together with 6 degrees of expansion in Blastocyst stage.

  • Early Blastocyst (1)
  • Blastocyst (2)
  • Full Blastocyst (3)
  • Expanded Blastocyst (4)
  • Hatching Blastocyst (5)
  • Hatched Blastocyst (6)

 

After grading, embryologists will thoroughly record the information of each embryo. The result from 3 parts will be evaluated together in order to identify the best embryo to transfer.

 

Related Posts

22

Apr
news knowledge-en

Edwards syndrome an abnormality of chromosome pair 18

Edwards syndrome an abnormality of chromosome pair 18 In addition to the popular disease Down syndrome, there is also “Edwards syndrome (Trisomy 18)”, which is a chromosomal abnormality that is found less frequently. Edwards syndrome is an abnormality of chromosome pair 18. Normally, babies have 23 pairs of chromosomes, 2 strands per pair. However, babies with Edwards syndrome have an extra 18strand, making this pair of chromosomes 3 strands. What causes Edwards syndrome? The factors that cause babies to have this type of chromosomal abnormality can occur in mothers of […]

17

Feb
news knowledge-en

Why do we need to have a dental check-up before pregnancy?

Why do we need to have a dental check-up before pregnancy? For women who are planning to get pregnant, another thing to consider is “dental check-ups.” It would help if you had an oral check-up to receive treatment to reduce the risk of oral infections. Because tooth decay or even gingivitis affects the quality of life of the mother during pregnancy, including involving the pregnancy, such as premature birth, and children being born with low weight. Therefore, knowing this, you should prepare to prevent these conditions from happening in the[…]