‘DNA Fragmentation’ How does this happen?

Deoxyribonucleic acid or DNA is a molecule of the organic compound that carries genetic information of an organism.

Resources: Fragmentation DNA | invitra.com

 

If the DNA is damaged or fragmented, it will result in cells’ malfunction. Therefore, when cell division occurs, these irregular traits will be inherited through generations, leading to mutation in next generations.

Sperm is male reproductive cell that fertilizes with ovum and inherits genetic traits to the next generation. As a result, sperm DNA damage could possibly lead to:

• Lower chance of fertilization
• Lower embryo quality
• Lower chance of embryo implantation
• Higher chance of miscarriage

Sperm DNA Fragmentation can occur from various causes such as oxidative stress, aging, smoking, pollution, or some inappropriate lifestyle. These factors could lead to higher oxydants in sperm, resulting in sperm’s malfunction or future mutation. Finally, these factors will damage DNA and lead to DNA fragmentation.

To examine the quality of sperm DNA, we follow the method called “the sperm chromatin dispersion test” (SCD) using the Halosperm G2 kit. After the process of DNA denaturation to extract protein from the head of the sperm, regular sperm DNA will produce the characteristic HALO around the head of the sperm. In contrast, if the sperm is damaged or has DNA fragmentation, the HALO will not or barely appear.

The result of the exam will be the guide to find further suitable treatments such as MACS Sperm or IMSI to help increase the success rate of infertility treatment.

 

Should you be interested in getting fertility consultation, please contact us. | ICSI Bangkok

Prime Fertility Center

Tel. : 062-648-6688 / 062-648-8866 / 02-029-1418–9
Line : http://line.me/ti/p/~@primefertility
Facebook : https://www.facebook.com/primefertilitycenter
E-mail : info@primefertilitycenter.com

Working Hours

  • Open: Monday – Wednesday, Friday and Saturday
    Time: 08:00 – 16:00
  • Closed: Thursday, Sunday and Public Holidays

 

409

Related Posts

17

Feb
news knowledge-en

Why do we need to have a dental check-up before pregnancy?

  • 17/02/2025

Why do we need to have a dental check-up before pregnancy? For women who are planning to get pregnant, another thing to consider is “dental check-ups.” It would help if you had an oral check-up to receive treatment to reduce the risk of oral infections. Because tooth decay or even gingivitis affects the quality of life of the mother during pregnancy, including involving the pregnancy, such as premature birth, and children being born with low weight. Therefore, knowing this, you should prepare to prevent these conditions from happening in the […]

Read Article

16

Nov
news knowledge-en

Frequent drinking and hangovers increase the risk of infertility

  • 16/11/2024

Frequent drinking and hangovers increase the risk of infertility

Frequent drinking and hangovers increase the risk of infertility

Frequent parties and hangovers can directly and indirectly affect your health, especially for those who are already planning to have children. This makes it even more difficult to have children!

Because frequent and large amounts of alcoholic beverages cause the hormones in the body to function abnormally.

What are the effects of drinking alcohol and hangovers?

In men > Abnormal testosterone production results in the body producing less sperm, poor quality sperm, and reduced fertilization ability.

In women > Abnormalities in the pituitary glands hormone system and hormones that control ovarian function result in no ovulation, abnormal uterine lining, and increased chances of premature birth or miscarriage.

It also reduces the absorption of vitamins and minerals, increasing the risk of malnutrition such as magnesium and potassium. It also comes with negative effects from a “hangover” such as insufficient sleep, restless sleep, headaches, dizziness, vomiting, dehydration, fatigue, etc. These are indirect negative effects that affect the body. 

Therefore, drinking excessive amounts of liquor, beer, wine, or other alcoholic beverages is a cause of infertility and reduces the chances of having children by up to 50%.

If anyone is planning a pregnancy and still has problems controlling their alcohol consumption, you may need to consider consulting a mental health professional or medical professional to find a treatment plan.

Prime Fertility Center does not only provide infertility treatment. What Prime Fertility Center aims for and continuously develops is to provide services to customers with care, consultation, care, and concern for all your feelings, like family members. Because we understand the feelings, pressure, and stress of those who cannot successfully conceive, the clinic intends to provide warmth and full convenience to those who receive services, with determination and care from a team of expert doctors, embryologists, and a team with extensive experience in providing comprehensive care and consultation.

Should you be interested in getting infertility consultation, please contact us.

Prime Fertility Center

Tel. : 062-648-6688 / 062-648-8866 / 02-029-1418–9
Line : @primefertility
Facebook : Prime Fertility Center
E-mail : info@primefertilitycenter.com

 

 

 

69
Read Article